The most intriguing rivalry of the 2025-26 NBA campaign will add another chapter when the Oklahoma City Thunder and San Antonio Spurs square off again in San Antonio on Wednesday night. Oklahoma City (40-11) won the most recent meeting at home on January 13, but San Antonio (33-16) still leads the season head-to-head series 3-1.
Let’s dive into my Thunder vs. Spurs predictions.
Oklahoma City Thunder vs. San Antonio Spurs odds
Money line: Thunder -130 / Spurs +110
Spread: Thunder -2.5 (-105) / Spurs +2.5 (-115)
Total: Over 226.5 (-110) / Under 226.5 (-110)
Oklahoma City Thunder vs. San Antonio Spurs best bet #1: Spurs +2.5 (-115)
This is a great spot for the Spurs, especially as slight underdogs. They crushed the Thunder 130-110 the last time these two rivals collided in San Antonio on December 23. Moreover, OKC is playing the second leg of a back-to-back situation after getting the best of Orlando at home on Tuesday night. Adding insult to injury for the visitors, Jalen Williams is likely to miss his ninth consecutive contest because of a hamstring problem. Williams is averaging 16.8 points, 5.6 assists and 4.8 rebounds per game, so his absence would obviously be critical.
The Thunder have cooled off of late, in part because they have been without Williams. The defending champions still boast the best record in the association, but they are just 3-4 in their last seven games and 5-5 in their last 10. San Antonio is 6-3 in its last nine overall and it has lost at home only once since January 3. Victor Wembanyama has scored 25 points or more in five of the last eight outings and has blocked four shots or more in four of the last five. Don’t be surprised if the home team wins this one outright.
Oklahoma City Thunder vs. San Antonio Spurs best player prop bet: Dylan Harper Over 9.5 points (-115)
Here comes Dylan Harper! It has taken the No. 2 overall pick a while to get going in his NBA career, but the rookie is heating up as we approach the all-star break. He has scored 16, 20, and 15 points in the last three games, consistently obliterating his season average of 10.7 ppg.
Harper has scored 12 points in each of the last two head-to-head matchups with Oklahoma City. He should be in line for another successful night on Wednesday, in part because fellow shooting guard Stephon Castle is in danger of missing his second straight contest due to a thigh injury. Castle is questionable, so he will either be sidelined or perhaps on a minutes restriction. Regardless, Harper should see plenty of court time.
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